The Lady Pirates improved to 4-11 overall and 2-0 in MEAC play.
Lupoe had a team-high 16 points on 8-for-12 shooting, while also grabbing a team-best 12 rebounds. She also had three blocks and three steals. Tate-DeFreitas became the first Hampton player since 2003 to record a triple-double, netting 13 points to go along with 11 rebounds and a career-high 10 assists.
The last Hampton triple double came when Lynetta Sullivan had 10 points, 10 rebounds, and 10 steals against Coppin State on Jan. 13, 2003.
Junior guard Georgianna Gilbeaux tied her career high with eight points.
The Lady Pirates shot 43.1 percent (22-for-51) from the floor, hitting three of their 16 3-pointers (18.8 percent). Hampton also hit 13 of 20 free throws (65.0 percent) and dominated the glass, out-rebounding the Wildcats 43-29.
Senior guard Ryan Jordan hit the first basket of the game, a 3-pointer at the 7:41 mark of the first quarter, before Bethune scored the next eight points. Hampton ended the quarter on a 6-2 run, closing the gap to 10-9 after 10 minutes of play.
Overall, the run ballooned to 10-2, giving the Lady Pirates a 13-10 lead at the 8:47 mark of the second quarter after a jumper from Tate-DeFreitas. Kendra Cooper hit a jumper 25 seconds later to make it a one-point game, but a Tate-DeFreitas trey started another Hampton run.
That run ultimately wound up being 21-4, which gave the Lady Pirates a 34-16 lead after a jumper from Gilbeaux with 21 seconds left in the half.
Hampton took that lead into the break. Lupoe had 10 points at the half.
The Lady Pirates shot 50.0 percent (14-for-28) from the floor in the first half, while holding the Wildcats to 22.7 percent shooting (5-for-22) in the opening 20 minutes.
Lupoe hit a layup with 7:48 left in the third quarter to give Hampton its largest lead of the game at 38-16. But the Wildcats scored the next seven points to cut the lead to 38-23 after a jumper from Alea Godfrey, and Godfrey added another jumper at the 1:37 mark to cut the lead to 41-27.
Hampton led 43-28 after three quarters, but Bethune opened the final frame with an 8-2 run, cutting the lead to 45-36 after a Kailyn Williams free throw at the 6:45 mark. A Cooper jumper with 4:31 to play cut the lead to 49-41.
But the Wildcats went cold from there, and the Lady Pirates responded by going on an 11-2 run – taking a 60-43 lead with 48 seconds remaining after a layup from junior guard Chanel Green.
Over that stretch, Bethune went 1-for-6 from the floor and had three turnovers.
The Wildcats (7-8, 1-1 MEAC) shot just 32.1 percent (17-for-53) from the floor and made three of 15 3-pointers (20.0 percent). Bethune only made eight of 16 free throws.
Cooper led three Wildcats in double figures with 13 points.
The Lady Pirates will play host to Florida A&M on Monday at 5 p.m. For more information on Hampton University basketball, please call the Office of Sports Information at (757) 727-5811, or visit the official Pirates website at www.hamptonpirates.com.